GREG'S LEGACY

Specialising in the human experience of Living with prostate cancer – warts and all

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Progesterone Balances Testosterone

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***** This is a reblog of a post Greg published on 23.06.2012. In view of my latest article I thought I would publish this again to add further information for those interested in this subject.******

Lee aka Popeye

FACT: USP natural progesterone builds bone density (osteoporosis)

If you are or have been on Hormone Therapy (ADT). you WILL get osteoporosis – a chalking of the bones.  Eventually, you WILL have what they term “A Skeletal Event” usually a fracture of a hip bone.  I did.  If it does nothing else, Progesterone WILL prevent that happening. – Greg

My “quality of life” was stolen by the hormone therapy (Zoladex + Androcur).   I was one of those who reacted badly to ADT.

But, I got it back no thanks to my to my medical team.  Inside 2 days, Natural Progesterone Cream turned everything around giving me back my vitality and quality of life.

Dr. John Lee, M.D. (deceased),  the author of several books including What Your Doctor May Not Tell You About Menopause, has found that progesterone for men is one of the most effective treatments for prostate cancer. He had a series of patients who had metastatic prostate cancer who went into complete remission with natural progesterone. Progesterone appears to turn on the anti-cancer gene p53.

Progesterone is a hormone manufactured in the body from the steroid hormone pregnenolone. Progesterone is a precursor to most of the other steroid hormones, including cortisol, androstenedione, the estrogens and testosterone.

As a precursor, it looks for weaknesses in the hormone balance and converts into whatever is needed to bring the balance back.  Traditional ‘ PC hormone therapy’ or ADT tries to do the same by reducing the testosterone.  It does not consider the ‘hormone balance’ option.

Both men and women produce all of the sex hormones (testosterone, estrogen, HGH, progesterone, cortisol, etc,).  We just use them in different quantities and for different purposes.  As we get older and no longer need as much of any one of them, we slow down on the production and the balance is lost leading to many forms of ill health.  Men also become estrogen dominant and suffer the same problems that women have during menopause. Progesterone fixes that and is also actively involved in the building of bones.

Our doctors are generally unaware of progesterone to treat prostate cancer.  My doctors ignored my requests until they could offer no further options.  I had to get a prescription from a doctor and then have the 4% cream made by a blending pharmacist.  They certainly make it difficult to access, don’t they!  I use 1 cc or 1 gram (measured by supplied spoon) both morning and night.  that is the equivalent of around 80mg a day.

My GP was so amazed with the result, he has prescribed it to other PC patients.  He believes it is effective for any hormone related tumours.

If your quality of life is being effected by your ‘Gold Standard’ treatment, give it a go.  You will find out if it helps within a few days.

USP natural progesterone refers to the progesterone substance that is exactly the same hormone that is made by the human body. USP natural progesterone is not the same as the ‘progestins‘ that are synthetic versions of progesterone sold by the pharmaceutical companies.

Natural USP progesterone can provide many health benefits for both men and women (read our important article on natural progesterone for more information) , but only if it’s USP progesterone, the only type that’s bio-identical to the naturally occurring progesterone in your body.

I get my Natural Progesterone Cream 100g 4% from MJ Health & Beauty online.

Related Articles:

Greg’s Legacy Posts about Progesterone:

Prostate Intervention Versus Observation Trial (PIVOT)

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A diagnosis of prostate cancer is shocking and most often quite unexpected. The thought of a tumour growing inside you is sickening.  Don’t rush into an operation … it could be the worst thing you do.

Almost immediately, men face a decision about treatment – and the first impulse is, for many, to want it cut out.

As an oncologist with more than 15 years specialising in the condition, you might expect me to agree.

But I urge patients not to be so hasty. Mounting evidence shows that surgery is not always the best treatment. Read Full Text:

SURGERY DOES NOT IMPROVE SURVIVAL

In the Prostate Intervention Versus Observation Trial (PIVOT), Half of the men underwent surgery to remove the prostate – known as ‘radical prostatectomy’ – the others did ‘watchful waiting’, which means they had no immediate treatment.

The results showed that on average those who underwent surgery were no more likely to survive than the watchful waiting group.  Read Full Text:

MEN WITH PROSTATE CANCER FREQUENTLY HAVE NO SYMPTOMS AT ALL

If the PSA levels are high or a change has occurred to the surface of the prostate, a biopsy is performed by taking tissue from the prostate with a needle.

If results come back with a PSA score above 20 or a Gleason score between 8 and 10, it is usually advisable to have immediate treatment. Read Full Text:

ACTIVE SURVEILLANCE MAY BE THE BEST OPTION

In those diagnosed with a PSA score lower than 10 and a Gleason score of 6, I would not normally advise surgery. Instead, I would usually recommend active surveillance – which is a halfway house between watchful waiting (doing nothing) and surgery.  The patient undergoes regular testing – MRI scans, blood tests and biopsies – to monitor the cancer.

Watchful waiting is an option for those who are very elderly or who have other serious medical problems.  Read Full Text:

THE PSYCHOLOGICAL HURDLE

It is important that a man who has been diagnosed with low-risk prostate cancer overcomes the psychological hurdle that he has a cancer inside him. Whether you suffer from low or high-risk cancer, there should be regular dialogue between your doctor, oncologist, urologist and yourself.

Apart from the specialists (oncologist, urologist, radiologist), you need a local doctor you can relate to to supervise your progress towards cure or not.  The specialists are only concerned with the tumour, they have no concern for the patient.

Take time to think over the options available to you as removing the prostate is a life-changing course of action.Read Full Text:

BE PROACTIVE BEFORE MAKING A DECISION

Ensure you check how experienced your surgeon is – they should be doing more than 50 prostate operations a year and you have every right to ask them if this is the case.

Something else that the study highlights is that too many men are being diagnosed with the cancer in the first place.  If low risk prostate cancer does not need any treatment then it does not need to be diagnosed either.

To my mind, when it comes to low risk prostate cancer ignorance really is bliss.

But perhaps the most important fact to be taken away from this recent trial is that if you are diagnosed with prostate cancer, many options are available to you.

Radical prostatectomy is not the only avenue you must explore and your quality of life may not need to be dramatically reduced. Read Full Text:

By DR CHRIS PARKER b

*** This is the final article published posthumously on behalf of Greg.

Written by Greg Naylor

17 February 2013 at 6:00 am

AXMAN REBLOG: Confusion Reigns

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Confusion Reigns

…so everything is just about normal.
Reblogged from Axman and Prostate CancerIf you have had prostate cancer for a while you may have noticed that there has been a lot of published research in the past several years designed to clarify the diagnosis and treatment process of the disease. Had you been paying attention you would have learned (from respected researchers) that:

  • Guys who are healthy and have never had a PSA test should generally not be tested. There is no survival advantage and there is the possibility of over treatment.
  • Some guys should be tested with the PSA if they and their doctor think it’s a good idea (for example if it runs in the family). And similar research in Europe has shown there does seem to be
    about a 20% survival advantage to having regular PSA tests.
  •  Younger men, newly diagnosed with slow growing prostate cancer, show no survival benefit from surgery. What about those with faster growing tumors or a high PSA?
  • Older men, newly diagnosed, show no survival benefit from surgery. Too bad.
  • Treatment of any kind may not show a significant survival benefit.
  • Treatment saves lives or extends lives for some (different researchers).

So, armed with this definitive scientific information, you and your medical team can confidently plan a treatment (or non-treatment) regimen to keep you as healthy as possible for as long as possible (don’t you feel more positive already?). I would certainly like to show a survival benefit. So far I’m surviving and that is definitely a survival benefit to me. 
Every man’s experience with prostate cancer is different, every man’s choices are a little different, every man’s attitude is a little different, every man’s response to treatment is a little different, every man’s tolerance of medical side effects is different, but we all  hope it works for us.

Greg says:

The research and trials are confusing and sometimes contradictory leaving us in a quandary if not a vacuum.  It seems the more we research our situation the more confused we can become.  Particularly when we are feeling unwell due to the disease and its treatment we are not in a position to make informed choices.

Nobody really knows what will work for any individual at any time. This is a good reason to be seriously involved in your own treatment. You know how you feel, what you want, what your side effects are, and what you are willing or not willing to do or tolerate.

Written by Greg Naylor

11 February 2013 at 6:00 am

Active Surveillance V Prostatectomy Cost Analysis

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July 24, 2012 — The cost of providing active surveillance for 10 years to a man with prostate cancer is about the same as the cost of initially performing surgery, according to an economic analysis published in the July 15 issue of Cancer.

The researchers estimated that 10 years of active surveillance costs $28,784 and that an initial radical prostatectomy — and the related 10 years of office follow-up — costs $31,612.

However, some other treatments for prostate cancer are much more expensive than these 2 options. The most expensive treatments include initial image-guided radiation therapy with short-term androgen-deprivation therapy (ADT), which costs $61,131 at 10 years, and long-term ADT, which costs $84,055 at 10 years.

Active Surveillance entails monitoring the cancer with everything except surgery, chemotherapy, hormone therapy (ADT) or radiation.  Should the condition deteriorate, these options will be assessed and a treatment modality will be chosen.

The costs in this article are what Americans pay.  It should be pretty much the same in Australia.  Fortunately for me, I am a pensioner with a ‘Health Card’ which means it is rare that I have to pay for anything – including medications once I reach the ‘Safety Net’ expenditure limit.  Being on a Health Card, I understand there are various treatments such as brachytherapy that are not covered under the Safety net.

Protocol and Individual Costs for Active Surveillance

Procedure Cost ($)
Prostate biopsy 1102
Pathology costs 660
Professional/technical fees 635
Office consultation 428
Office visit 118
PSA measurement 52
Urologist reimbursement for biopsy 433

The protocol consists of an initial office consultation, 2 prostate biopsies within the first 3 months (diagnostic and confirmatory), pathology costs, professional & technical fees, prostate-specific antigen (PSA) values, and office visits every 3 months for 2 years and every 6 months thereafter.

As noted above, repeat prostate biopsy was performed after the second year of follow-up and every other year thereafter.

For the economic analysis, the researchers assumed that 7.0% of the 120,000 men on active surveillance will exit observation and receive treatment (in years 1 to 5), and that 4.5% will do so later on (years 6 to 10). In total, 30% and 45% will exit by years 5 and 10, respectively, which is in keeping with clinical studies.

In the analysis, the men exiting active surveillance were distributed between different forms of common treatment for localized prostate cancer, including (listed with associated probability) radical prostatectomy (40%), image-guided radiation therapy with or without ADT (25% and 10%, respectively), prostate brachytherapy (15%), and ADT monotherapy (10%).

Written by Greg Naylor

25 January 2013 at 6:00 am

One family’s end of life decisions

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One family’s journey through hospice is painful as well as beautiful and inspiring.

I do not know Terence Lutrell or his wife Sherry. But I know their touching story. It is a gut wrenching, highly charged, emotional story showing the extent of care required if one is to die at home.  It has reinforced my choice to die in hospital so that I do not inflict my wife/carer Pauline to the indignity of wiping my bum and all those other less than appealing jobs that our nurses are trained to do.

There are two facts about prostate cancer: many survive, but many with advanced disease do not. Unfortunately, Terrence lost his battle but he was a fortunate man to be surrounded with the warmth of loving family and friends. Here is Sherry’s post:  (Source)

Today was very long and heart breaking day; many tears- some from sadness and some from gratefulness for the moment. Terence was in and out of consciousness and completely unable to do things for himself (swallow, eat, drink for starters)- it’s taking a small village (our family) to keep up with the needs on this one household dealing with end stage cancer. My sisters, Brook and Charla. I don’t have the words. Both are here 24/7 waiting on Terence hand and foot- guessing- “Does he want water? Do you think he wants ice cream?” (he is losing his ability to speak) they feed him once they figure it out what he wants. That’s not even the messy side of care giving, but they’re there for that too.

My brothers in-laws…. John and Dave. They spent the past few days here fixing stuff and making stuff easier for Terence.

Even though hospice said Terence wouldn’t be up and about (bed bound) they re-vamped the shower and bathroom to make it easier for me to help him take a shower. They fixed electrical outlets, my doors, installed dimmers … they’ve been busy helping to make life a little easier around here. Dave reset all my clocks and figured out the remote control for me.

The past few days have been gruesome. Watching Terence try to accomplish some of the simpler things like swallowing his pills, or even water. He breaks down and weeps sometimes because he knows and he gets mad or really sad. When he cries my heart breaks into a bajillion pieces. By the end of two or three weeping sessions of his, I usually go someplace he can’t see me and I cry. Really hard. If he sees me crying, he tries to console me. He whispers, “shhhhh” and tries to reach for my face. My heart actually hurts.

The hospice nurse had to come today since Terence can’t swallow his pills- so the morphine pump was introduced. We three sisters were schooled on the pump. His massage therapist came by and massaged him. Then she went out to her car and brought her table in, set it up next to Terence’s bed and gave me a massage. I couldn’t stop crying. (Continue …)

Tomorrow would be a great day for a miracle.

Greg

A Note from Lee aka Popeye

Terrence died on 14 August, 2012.  Sherry, we wish you peace and strength. You already share abundant love.

Greg died from prostate cancer 24th September 2012 and as per his wishes he was at hospital and not at home. Pauline was surrounded by love and strength from all the family and friends.

Sadly, in Australia, one man dies like this from prostate cancer every three hours. Perhaps 2013 may bring advances to find a cure for all types of cancer.

Written by Greg Naylor

11 December 2012 at 6:00 am

Weed Killer Drug Kills Prostate Cancer Cells

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Researchers have announced the development of a novel, anticancer drug (G202) that has been described as a molecular grenade that targets cancer cells. The drug is able to travel undetected by normal cells through the bloodstream until it is activated by a specific cancer proteins, then kaboom!

The drug, which is made from a weed, has been shown to destroy the cancer cells and their direct blood supplies while sparing healthy blood vessels and tissues.

In studies G202 is administered over three days. So far the drug reduced the size of human prostate tumors grown in mice (not humans) by an average of 50 percent within 30 days. To give you a comparative understanding, G202 outperformed docetaxel. G202 reduced seven of nine human prostate tumors in mice by more than 50 percent in 21 days. Docetaxel reduced one of eight human prostate tumors in mice by more than 50 percent in the same time period.

According to a report in the June 27 journal, Science Translational Medicine, the researchers also reported that G202 produced at least 50 percent regression in models of human breast cancer, kidney cancer and bladder cancer.

Because of these great mouse model results, researchers at Johns Hopkins have performed a phase I clinical trial to assess safety of the drug. So far they have treated 29 men with advanced cancer. In addition to Johns Hopkins, the University of Wisconsin and the University of Texas-San Antonio are participating in the trial. A phase II trial to test the drug in patients with prostate cancer and liver cancer is planned. I will let you know when these trials are started.

The drug G202 is chemically derived from a weed that grows in the Mediterranean region. The weed has since the time of ancient Greece has been known to be toxic to animals. In Arab caravans, the plant was known as the “death carrot” because it would kill camels if they ate it.

The drug is injected and then travels through the bloodstream until it finds the site of the cancer cells. When it meets the cancer cells it is exposed to a protein called prostate-specific membrane antigen (PSMA). PSMA is released by cells lining tumors of the prostate and other areas, and in effect “pulls the pin” on G202, releasing cell-killing agents into the tumor and the blood vessels that feed it, as well as to other cells in the vicinity.

Again, we are looking at a number of exciting, new drug potentials to combat this dread disease, advanced prostate cancer.

Other referemces:

Written by Greg Naylor

29 November 2012 at 6:00 am

Diabetes drug shrinks tumours

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A diabetes drug costing as  little as 2p a tablet could offer a major breakthrough in the treatment of prostate cancer.  Research has shown that the medicine, called metformin(fact sheet) causes tumours to shrink by slowing the rate at which cancerous cells grow.

Metformin 500mg tablets

Metformin 500mg tablets (Photo credit: Wikipedia)

If the results are confirmed in bigger trials, it raises the possibility that men could be given the cheap, readily available drug as soon as they are diagnosed.

Metformin is widely used on the NHS to treat patients with type 2 diabetes.

But recent studies highlighting the drug’s effects against a variety of tumours have generated considerable excitement among cancer researchers looking for powerful new treatments.

Last year, scientists discovered it could slash the risk of ovarian cancer by around 40 per cent.

In the latest breakthrough, doctors tested the drug on 22 men who were due to undergo surgery to have their prostates removed.

For six weeks before their operation, each one took 500mg of metformin three times a day, during which time researchers measured the rate at which the tumour cells multiplied.

The results, presented at the recent American Association for Cancer Research annual meeting in Chicago, showed malignant cells grew at a significantly slower rate once the men were put on the drug, suggesting metformin might be able to keep tumours under control.

Metformin works by reducing the amount of glucose produced by the liver and helping cells mop up sugar that is circulating in the bloodstream, preventing damage from excessive blood sugar levels.

At about £30 per patient per year – or just 6p to 8p a day – it could be a highly cost-effective way to tackle prostate tumours.

This looks promising and could be acted upon before larger scale trials are completed.  The drug is already familiar to our doctors who should be able to evaluate its voracity to help youGreg

By Pat Hagan |

Written by Greg Naylor

24 November 2012 at 6:00 am